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CFDE Workbench

SIRT3 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:23410, HGNC:14931, MIM:604481, NM_001017524, NM_001370310, NM_001370312, NM_001370314, NM_001370315, NM_001370316, NM_001370317, NM_001370318, NM_001370319, NM_001370320, NM_001370321, NM_001370322, NM_001370323, NM_001370324, NM_001370325, NM_012239, NP_001017524, NP_001357239, NP_001357241, NP_001357243, NP_001357244, NP_001357245, NP_001357246, NP_001357247, NP_001357248, NP_001357249, NP_001357250, NP_001357251, NP_001357252, NP_001357253, NP_001357254, NP_036371, NR_163386, NR_163387, NR_163388, NR_163389, NR_163390, NR_163391, NR_163392, NR_163393, NR_163394, NR_163395, NR_163396, NR_163397, NR_163398, NR_163399, NR_163400, NR_163401, NR_163402, SIR2L3, SIRT3, XM_011519956, XM_011519957, XM_017017431, XM_024448410, XP_011518258, XP_011518259, XP_016872920, XP_024304178, sirtuin 3
Omim:OMIM:604481
Id:ENSG00000142082
Hgnc:HGNC:14931
Entrez:23410
Ensembl:ENSG00000142082
Description:sirtuin 3
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SIRT3's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SIRT3.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SIRT3.

Submit
Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SIRT3.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SIRT3.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE261563 CX-5461 7 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE158834 ADIPOR2 knockout HEK293 0 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE183535 MYC inhibition HeLa 3 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE232435 TAK1 inhibition 0 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE108464 AZ-628 1 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE223893 SETD2 PARP inhibition kidney 4 v 10 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE158834 0 V 8 PALMITIC ACID HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE195503 progesterone 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE210655 3 V 0 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE193258,GSE193259 9 V 15 OSIMERTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE261563 CX-5461 7 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE158834 ADIPOR2 knockout HEK293 0 v 8 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE183535 MYC inhibition HeLa 3 v 6 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE232435 TAK1 inhibition 0 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 1 v 5 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE223893 SETD2 PARP inhibition kidney 4 v 10 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE158834 0 V 8 PALMITIC ACID HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE195503 progesterone 3 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE210655 3 V 0 CISPLATIN MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193258,GSE193259 9 V 15 OSIMERTINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.