4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KPNA2 Gene (Entity type)	0.004950875
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CKS2 Gene (Entity type)	0.005069343
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MDK Gene (Entity type)	-0.0033574884
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Aurora kinase A Protein (Entity type)	Kd
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HLA-B Gene (Entity type)	-0.0038069529
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	NMS-P937 Compound (Entity type)	0.5518474578857422
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MCM5 Gene (Entity type)	-0.0037249422
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TFPI2 Gene (Entity type)	0.0046345675
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase 17B Protein (Entity type)	Kd
4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Tivantinib Compound (Entity type)	0.5342501997947693

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KPNA2
Gene (Entity type)
0.004950875

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CKS2
Gene (Entity type)
0.005069343

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MDK
Gene (Entity type)
-0.0033574884

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Aurora kinase A
Protein (Entity type)
Kd

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HLA-B
Gene (Entity type)
-0.0038069529

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
NMS-P937
Compound (Entity type)
0.5518474578857422

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MCM5
Gene (Entity type)
-0.0037249422

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TFPI2
Gene (Entity type)
0.0046345675

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase 17B
Protein (Entity type)
Kd

4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Tivantinib
Compound (Entity type)
0.5342501997947693

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Knowledge Graph Assertions

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