[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View [3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)'s neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ARG1 Gene (Entity type)	0.008780501
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CFB Gene (Entity type)	0.009922392
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EPS8 Gene (Entity type)	-0.010214901
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CLIC4 Gene (Entity type)	-0.009871652
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PERP Gene (Entity type)	-0.009874801
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GZMA Gene (Entity type)	0.01288685
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PSMB9 Gene (Entity type)	0.00865134
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRAME Gene (Entity type)	-0.010740606
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFRD2 Gene (Entity type)	0.009834143
[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSPB8 Gene (Entity type)	0.009588438

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ARG1
Gene (Entity type)
0.008780501

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CFB
Gene (Entity type)
0.009922392

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EPS8
Gene (Entity type)
-0.010214901

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CLIC4
Gene (Entity type)
-0.009871652

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PERP
Gene (Entity type)
-0.009874801

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GZMA
Gene (Entity type)
0.01288685

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PSMB9
Gene (Entity type)
0.00865134

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRAME
Gene (Entity type)
-0.010740606

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFRD2
Gene (Entity type)
0.009834143

[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid (ponalrestat)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HSPB8
Gene (Entity type)
0.009588438

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.