4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TRIM22 Gene (Entity type)	0.0035823828
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SV2C Gene (Entity type)	-0.0018821269
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SCGB2A2 Gene (Entity type)	-0.0022654573
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLA2G2A Gene (Entity type)	0.002419655
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOLR1 Gene (Entity type)	-0.0020881898
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IER3 Gene (Entity type)	0.002558842
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0019418775
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NUPR1 Gene (Entity type)	-0.0018775115
AZD-1152 HQPA Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	0.3792263567447662
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TNFRSF10B Gene (Entity type)	0.002648213

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TRIM22
Gene (Entity type)
0.0035823828

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SV2C
Gene (Entity type)
-0.0018821269

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SCGB2A2
Gene (Entity type)
-0.0022654573

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLA2G2A
Gene (Entity type)
0.002419655

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOLR1
Gene (Entity type)
-0.0020881898

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IER3
Gene (Entity type)
0.002558842

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0019418775

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NUPR1
Gene (Entity type)
-0.0018775115

AZD-1152 HQPA
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
0.3792263567447662

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TNFRSF10B
Gene (Entity type)
0.002648213

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Knowledge Graph Assertions

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