PLEKHM1 (Gene)

Entrez Gene ID: 9842

Description: pleckstrin homology and RUN domain containing M1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PLEKHM1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PLEKHM1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PLEKHM1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PLEKHM1.

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Gene Sets (2339)

LINCS L1000 Chem Pert Consensus Sigs (759)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (12)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (670)

A gene set library provided by LINCS

rummageo gene perturbations (162)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (540)

A gene set library provided by LINCS

rummageo chemical perturbations (193)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
amiprilose Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0035971473
3-Methyl-1-propyl-3,7-dihydro-purine-2,6-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	0.0027394579
sericetin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.011222165
lodoxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0049918597
Desvenlafaxine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	0.0035852112
4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0019418775
Cyclophosphamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	0.0031847784
mirtazapine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0045907195
Diflunisal Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	-0.0032653941
5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLEKHM1 Gene (Entity type)	0.020938022

amiprilose
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0035971473

3-Methyl-1-propyl-3,7-dihydro-purine-2,6-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
0.0027394579

sericetin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.011222165

lodoxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0049918597

Desvenlafaxine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
0.0035852112

4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one::Acylpiperazine analogue, 47::Olaparib::US9187430, AZD-2281::US9255106, AZD2281
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0019418775

Cyclophosphamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
0.0031847784

mirtazapine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0045907195

Diflunisal
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
-0.0032653941

5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLEKHM1
Gene (Entity type)
0.020938022

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.