N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RPL26L1 Gene (Entity type)	0.002452591
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NR3C1 Gene (Entity type)	0.0026942014
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINF1 Gene (Entity type)	-0.00365223
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PHLDA1 Gene (Entity type)	0.0025216062
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITGAE Gene (Entity type)	0.0022620603
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MFAP5 Gene (Entity type)	-0.003080393
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IGFBP2 Gene (Entity type)	0.0029961786
Empagliflozin Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	0.2772128283977508
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUOX2 Gene (Entity type)	0.0026983148
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RRS1 Gene (Entity type)	0.0025711255

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RPL26L1
Gene (Entity type)
0.002452591

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NR3C1
Gene (Entity type)
0.0026942014

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINF1
Gene (Entity type)
-0.00365223

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PHLDA1
Gene (Entity type)
0.0025216062

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITGAE
Gene (Entity type)
0.0022620603

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MFAP5
Gene (Entity type)
-0.003080393

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IGFBP2
Gene (Entity type)
0.0029961786

Empagliflozin
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
0.2772128283977508

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUOX2
Gene (Entity type)
0.0026983148

N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RRS1
Gene (Entity type)
0.0025711255

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