N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EREG Gene (Entity type)	0.004874505
7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	0.2350838482379913
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DUSP6 Gene (Entity type)	0.004927039
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	EGR1 Gene (Entity type)	0.0051072813
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Dual specificity mitogen-activated protein kinase kinase 5 Protein (Entity type)	Kd
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NFATC3 Gene (Entity type)	-0.0046465904
SID103905642 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	0.5339112281799316
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TMT1A Gene (Entity type)	-0.0038253984
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSPB8 Gene (Entity type)	-0.0052081635
SAR-245408 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Compound (Entity type)	0.35151407122612

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EREG
Gene (Entity type)
0.004874505

7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
0.2350838482379913

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DUSP6
Gene (Entity type)
0.004927039

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
EGR1
Gene (Entity type)
0.0051072813

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Dual specificity mitogen-activated protein kinase kinase 5
Protein (Entity type)
Kd

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NFATC3
Gene (Entity type)
-0.0046465904

SID103905642
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
0.5339112281799316

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TMT1A
Gene (Entity type)
-0.0038253984

N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSPB8
Gene (Entity type)
-0.0052081635

SAR-245408
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Compound (Entity type)
0.35151407122612

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