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Ponatinib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Ponatinib's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	HKI-272 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.660050630569458
	Ponatinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor-interacting serine/threonine-protein kinase 3 Protein (Entity type)	IC50
	Drotaverine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.3199640214443207
	GW-441756 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.3216167390346527
	Ponatinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EGR3 Gene (Entity type)	-0.006943257
	Ponatinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proto-oncogene tyrosine-protein kinase receptor Ret Protein (Entity type)	IC50
	Ponatinib Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Philadelphia chromosome positive chronic myelogenous leukemia Disease or Phenotype (Entity type)
	Ponatinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Fibroblast growth factor receptor 2 Protein (Entity type)	IC50
	Ponatinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	XPOT Gene (Entity type)	0.008188534
	3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.5596975684165955

HKI-272
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.660050630569458

Ponatinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor-interacting serine/threonine-protein kinase 3
Protein (Entity type)
IC50

Drotaverine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.3199640214443207

GW-441756
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.3216167390346527

Ponatinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EGR3
Gene (Entity type)
-0.006943257

Ponatinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein (Entity type)
IC50

Ponatinib
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Philadelphia chromosome positive chronic myelogenous leukemia
Disease or Phenotype (Entity type)

Ponatinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Fibroblast growth factor receptor 2
Protein (Entity type)
IC50

Ponatinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
XPOT
Gene (Entity type)
0.008188534

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.5596975684165955

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