2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SLC37A4 Gene (Entity type)	0.004672582
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	METRN Gene (Entity type)	0.0051795263
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SEL1L3 Gene (Entity type)	0.0048125577
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(S)-4-Amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7Hpyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide Compound (Entity type)	0.2072020322084427
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MXRA7 Gene (Entity type)	0.00494641
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RTN2 Gene (Entity type)	-0.006139928
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Metabotropic glutamate receptor 5 Protein (Entity type)	IC50
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C3 Gene (Entity type)	-0.0064356616
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RNF167 Gene (Entity type)	0.004927816
2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TNFSF10 Gene (Entity type)	-0.0059270184

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SLC37A4
Gene (Entity type)
0.004672582

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
METRN
Gene (Entity type)
0.0051795263

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SEL1L3
Gene (Entity type)
0.0048125577

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(S)-4-Amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7Hpyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Compound (Entity type)
0.2072020322084427

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MXRA7
Gene (Entity type)
0.00494641

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RTN2
Gene (Entity type)
-0.006139928

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Metabotropic glutamate receptor 5
Protein (Entity type)
IC50

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C3
Gene (Entity type)
-0.0064356616

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RNF167
Gene (Entity type)
0.004927816

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TNFSF10
Gene (Entity type)
-0.0059270184

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