(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRPM4 Gene (Entity type)	-0.0043794583
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NVL Gene (Entity type)	-0.0052241813
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Montelukast Compound (Entity type)	0.1337231248617172
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MXRA7 Gene (Entity type)	-0.004594006
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TTN Gene (Entity type)	0.0053452873
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ZNF395 Gene (Entity type)	-0.008580612
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TARBP1 Gene (Entity type)	0.0060177124
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PGAM1 Gene (Entity type)	-0.0060338425
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FABP1 Gene (Entity type)	0.0057087387
(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WASHC4 Gene (Entity type)	-0.005435615

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRPM4
Gene (Entity type)
-0.0043794583

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NVL
Gene (Entity type)
-0.0052241813

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Montelukast
Compound (Entity type)
0.1337231248617172

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MXRA7
Gene (Entity type)
-0.004594006

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TTN
Gene (Entity type)
0.0053452873

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ZNF395
Gene (Entity type)
-0.008580612

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TARBP1
Gene (Entity type)
0.0060177124

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PGAM1
Gene (Entity type)
-0.0060338425

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FABP1
Gene (Entity type)
0.0057087387

(3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WASHC4
Gene (Entity type)
-0.005435615

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