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Palbociclib; Ibrance (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Palbociclib; Ibrance's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MXRA5 Gene (Entity type)	0.008253725
	Palbociclib; Ibrance Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cyclin-dependent kinase 2 Protein (Entity type)	IC50
	Palbociclib; Ibrance Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRC1 Gene (Entity type)	-0.015503199
	Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFI27 Gene (Entity type)	0.012064976
	N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Palbociclib; Ibrance Compound (Entity type)	0.3945709764957428
	Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINE2 Gene (Entity type)	0.007403145
	Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LAMC2 Gene (Entity type)	0.007878277
	RG7112 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Palbociclib; Ibrance Compound (Entity type)	0.4754864275455475
	Palbociclib; Ibrance Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCNB2 Gene (Entity type)	-0.015199431
	Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KRT7 Gene (Entity type)	0.007964587

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MXRA5
Gene (Entity type)
0.008253725

Palbociclib; Ibrance
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cyclin-dependent kinase 2
Protein (Entity type)
IC50

Palbociclib; Ibrance
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRC1
Gene (Entity type)
-0.015503199

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFI27
Gene (Entity type)
0.012064976

N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Palbociclib; Ibrance
Compound (Entity type)
0.3945709764957428

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINE2
Gene (Entity type)
0.007403145

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LAMC2
Gene (Entity type)
0.007878277

RG7112
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Palbociclib; Ibrance
Compound (Entity type)
0.4754864275455475

Palbociclib; Ibrance
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCNB2
Gene (Entity type)
-0.015199431

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KRT7
Gene (Entity type)
0.007964587

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