Palbociclib; Ibrance (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Palbociclib; Ibrance's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MXRA5 Gene (Entity type)	0.008253725
Palbociclib; Ibrance Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cyclin-dependent kinase 2 Protein (Entity type)	IC50
Palbociclib; Ibrance Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PRC1 Gene (Entity type)	-0.015503199
Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFI27 Gene (Entity type)	0.012064976
N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Palbociclib; Ibrance Compound (Entity type)	0.3945709764957428
Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINE2 Gene (Entity type)	0.007403145
Palbociclib; Ibrance Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LAMC2 Gene (Entity type)	0.007878277
RG7112 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Palbociclib; Ibrance Compound (Entity type)	0.4754864275455475
Palbociclib; Ibrance Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Human epidermal growth factor 2 negative carcinoma of breast Disease or Phenotype (Entity type)
Palbociclib; Ibrance Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCNB2 Gene (Entity type)	-0.015199431

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MXRA5
Gene (Entity type)
0.008253725

Palbociclib; Ibrance
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cyclin-dependent kinase 2
Protein (Entity type)
IC50

Palbociclib; Ibrance
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PRC1
Gene (Entity type)
-0.015503199

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFI27
Gene (Entity type)
0.012064976

N-{2-[(1S,4R)-6-(4-Cyclobutylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl]-2-oxo-ethyl}-acetamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Palbociclib; Ibrance
Compound (Entity type)
0.3945709764957428

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINE2
Gene (Entity type)
0.007403145

Palbociclib; Ibrance
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LAMC2
Gene (Entity type)
0.007878277

RG7112
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Palbociclib; Ibrance
Compound (Entity type)
0.4754864275455475

Palbociclib; Ibrance
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Human epidermal growth factor 2 negative carcinoma of breast
Disease or Phenotype (Entity type)

Palbociclib; Ibrance
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCNB2
Gene (Entity type)
-0.015199431

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