6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0027634355
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TARBP1 Gene (Entity type)	0.0035069603
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.0033821838
GSK-J1 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	0.4544244110584259
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DLC1 Gene (Entity type)	-0.002644548
4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	0.5265305042266846
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NNMT Gene (Entity type)	-0.0031335843
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DAXX Gene (Entity type)	0.0027141273
SID11112767 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	0.2570374608039856
Pirlindole Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	0.2455594092607498

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0027634355

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TARBP1
Gene (Entity type)
0.0035069603

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.0033821838

GSK-J1
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
0.4544244110584259

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DLC1
Gene (Entity type)
-0.002644548

4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl)-1H-pyrrole-2-carboxamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
0.5265305042266846

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NNMT
Gene (Entity type)
-0.0031335843

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DAXX
Gene (Entity type)
0.0027141273

SID11112767
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
0.2570374608039856

Pirlindole
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
0.2455594092607498

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Knowledge Graph Assertions

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