5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MT1F Gene (Entity type)	-0.0025162825
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	ruxolitinib Compound (Entity type)	0.4064784049987793
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLBD1 Gene (Entity type)	0.002896358
carbon-tetrachloride Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	0.3120741546154022
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PUF60 Gene (Entity type)	-0.002377928
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAOB Gene (Entity type)	-0.0022840984
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CKS2 Gene (Entity type)	0.0023904443
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYZ Gene (Entity type)	0.0026393295
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity nerve growth factor receptor Protein (Entity type)	IC50
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCL19 Gene (Entity type)	0.0032767795

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MT1F
Gene (Entity type)
-0.0025162825

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
ruxolitinib
Compound (Entity type)
0.4064784049987793

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLBD1
Gene (Entity type)
0.002896358

carbon-tetrachloride
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
0.3120741546154022

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PUF60
Gene (Entity type)
-0.002377928

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAOB
Gene (Entity type)
-0.0022840984

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CKS2
Gene (Entity type)
0.0023904443

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LYZ
Gene (Entity type)
0.0026393295

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity nerve growth factor receptor
Protein (Entity type)
IC50

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCL19
Gene (Entity type)
0.0032767795

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