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ruxolitinib (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ruxolitinib's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	ruxolitinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL9 Gene (Entity type)	0.0034778018
	ruxolitinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	YME1L1 Gene (Entity type)	0.003825406
	5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	ruxolitinib Compound (Entity type)	0.4064784049987793
	ruxolitinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TFPI Gene (Entity type)	-0.0041284016
	GSK-1838705A Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	ruxolitinib Compound (Entity type)	0.3206968903541565
	ruxolitinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	S100P Gene (Entity type)	-0.0037904282
	ruxolitinib Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	venetoclax Compound (Entity type)	0.4569264054298401
	ruxolitinib Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase JAK1 Protein (Entity type)	IC50
	ruxolitinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CDC25A Gene (Entity type)	0.0038646772
	ruxolitinib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HMOX1 Gene (Entity type)	-0.0043619806

ruxolitinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL9
Gene (Entity type)
0.0034778018

ruxolitinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
YME1L1
Gene (Entity type)
0.003825406

5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
ruxolitinib
Compound (Entity type)
0.4064784049987793

ruxolitinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TFPI
Gene (Entity type)
-0.0041284016

GSK-1838705A
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
ruxolitinib
Compound (Entity type)
0.3206968903541565

ruxolitinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
S100P
Gene (Entity type)
-0.0037904282

ruxolitinib
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
venetoclax
Compound (Entity type)
0.4569264054298401

ruxolitinib
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase JAK1
Protein (Entity type)
IC50

ruxolitinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CDC25A
Gene (Entity type)
0.0038646772

ruxolitinib
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HMOX1
Gene (Entity type)
-0.0043619806

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