(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Focal adhesion kinase 1 Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	BDNF/NT-3 growth factors receptor Protein (Entity type)	Ki
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein-tyrosine kinase 2-beta Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proto-oncogene tyrosine-protein kinase ROS Protein (Entity type)	Ki
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fes/Fps Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fer Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Non-Small Cell Lung Carcinoma Disease or Phenotype (Entity type)
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity nerve growth factor receptor Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	ALK tyrosine kinase receptor Protein (Entity type)	Ki
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Anaplastic lymphoma kinase fusion oncogene positive non-small cell lung cancer Disease or Phenotype (Entity type)

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Focal adhesion kinase 1
Protein (Entity type)
IC50

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
BDNF/NT-3 growth factors receptor
Protein (Entity type)
Ki

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein-tyrosine kinase 2-beta
Protein (Entity type)
IC50

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proto-oncogene tyrosine-protein kinase ROS
Protein (Entity type)
Ki

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Fes/Fps
Protein (Entity type)
IC50

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Fer
Protein (Entity type)
IC50

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Non-Small Cell Lung Carcinoma
Disease or Phenotype (Entity type)

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity nerve growth factor receptor
Protein (Entity type)
IC50

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
ALK tyrosine kinase receptor
Protein (Entity type)
Ki

(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Anaplastic lymphoma kinase fusion oncogene positive non-small cell lung cancer
Disease or Phenotype (Entity type)

DISPLAY PER PAGE

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
Loading results...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.