(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Focal adhesion kinase 1 Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	BDNF/NT-3 growth factors receptor Protein (Entity type)	Ki
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein-tyrosine kinase 2-beta Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proto-oncogene tyrosine-protein kinase ROS Protein (Entity type)	Ki
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fes/Fps Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fer Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Anaplastic lymphoma kinase fusion oncogene positive non-small cell lung cancer Disease or Phenotype (Entity type)
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity nerve growth factor receptor Protein (Entity type)	IC50
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Non-Small Cell Lung Carcinoma Disease or Phenotype (Entity type)
(10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h]-[2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	ALK tyrosine kinase receptor Protein (Entity type)	Ki