2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TACSTD2 Gene (Entity type)	-0.0101220915
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	BTBD3 Gene (Entity type)	-0.009762408
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TFF3 Gene (Entity type)	0.01172317
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-(6-Chloro-pyridin-3-yl)-5-methyl-7-aza-bicyclo[2.2.1]heptane Compound (Entity type)	0.3084084987640381
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Berberine Compound (Entity type)	0.2462315261363983
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ANXA5 Gene (Entity type)	0.009166158
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CASP2 Gene (Entity type)	0.009031314
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	SB-683698 Compound (Entity type)	0.2607637047767639
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TGM2 Gene (Entity type)	-0.01123318
2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RCN1 Gene (Entity type)	0.009376352

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TACSTD2
Gene (Entity type)
-0.0101220915

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
BTBD3
Gene (Entity type)
-0.009762408

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TFF3
Gene (Entity type)
0.01172317

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-(6-Chloro-pyridin-3-yl)-5-methyl-7-aza-bicyclo[2.2.1]heptane
Compound (Entity type)
0.3084084987640381

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Berberine
Compound (Entity type)
0.2462315261363983

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ANXA5
Gene (Entity type)
0.009166158

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CASP2
Gene (Entity type)
0.009031314

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
SB-683698
Compound (Entity type)
0.2607637047767639

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TGM2
Gene (Entity type)
-0.01123318

2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-4,4-dimethyl-4H-isoquinoline-1,3-dione
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RCN1
Gene (Entity type)
0.009376352

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