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Mitotane (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Mitotane's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Mitotane Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Sodium-dependent noradrenaline transporter Protein (Entity type)	IC50
	Mitotane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GNAS Gene (Entity type)	-0.006462011
	Mitotane Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAP7 Gene (Entity type)	0.0069307396
	Mitotane Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Carcinoma in situ of adrenal cortex Disease or Phenotype (Entity type)
	Mitotane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CYP4B1 Gene (Entity type)	-0.00516591
	Mitotane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CEACAM6 Gene (Entity type)	-0.0050074486
	Mitotane Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	VCAM1 Gene (Entity type)	0.0050717634
	Mitotane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ALDH1A1 Gene (Entity type)	-0.009247165
	Mitotane Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MMP9 Gene (Entity type)	0.0068587153
	Mitotane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAC8 Gene (Entity type)	-0.006918272

Mitotane
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Sodium-dependent noradrenaline transporter
Protein (Entity type)
IC50

Mitotane
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GNAS
Gene (Entity type)
-0.006462011

Mitotane
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MAP7
Gene (Entity type)
0.0069307396

Mitotane
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Carcinoma in situ of adrenal cortex
Disease or Phenotype (Entity type)

Mitotane
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CYP4B1
Gene (Entity type)
-0.00516591

Mitotane
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CEACAM6
Gene (Entity type)
-0.0050074486

Mitotane
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
VCAM1
Gene (Entity type)
0.0050717634

Mitotane
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ALDH1A1
Gene (Entity type)
-0.009247165

Mitotane
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MMP9
Gene (Entity type)
0.0068587153

Mitotane
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAC8
Gene (Entity type)
-0.006918272

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