2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DAPK1 Gene (Entity type)	0.011848085
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	0.011857831
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	JMJD6 Gene (Entity type)	-0.01778805
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SDF2L1 Gene (Entity type)	-0.010399142
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPX4 Gene (Entity type)	0.012015512
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAC8 Gene (Entity type)	-0.009871582
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KDM3A Gene (Entity type)	0.013243792
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Protein (Entity type)	IC50
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ENPP1 Gene (Entity type)	0.011265337
2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCDC86 Gene (Entity type)	-0.0104839755

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DAPK1
Gene (Entity type)
0.011848085

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
0.011857831

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
JMJD6
Gene (Entity type)
-0.01778805

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SDF2L1
Gene (Entity type)
-0.010399142

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPX4
Gene (Entity type)
0.012015512

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAC8
Gene (Entity type)
-0.009871582

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KDM3A
Gene (Entity type)
0.013243792

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Protein (Entity type)
IC50

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ENPP1
Gene (Entity type)
0.011265337

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCDC86
Gene (Entity type)
-0.0104839755

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Knowledge Graph Assertions

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