MAP4K4 (Gene)

Description: mitogen-activated protein kinase kinase kinase kinase 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MAP4K4's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MAP4K4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MAP4K4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MAP4K4.

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Gene Sets (1226)

LINCS L1000 Chem Pert Consensus Sigs (634)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (569)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (7)

A gene set library provided by GTEx

IDG Drug Targets 2022 (11)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Pridinol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	0.03348946
Lumiracoxib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.0053513907
pirinixic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.0096581
LY456236 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.0040696985
SD-6-035-A2 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.009658439
ethaverine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.0061674425
KFGENEBIN:MAP4K4-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)
3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	0.0036618793
3,5-DHPG Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.010722976
ML218 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAP4K4 Gene (Entity type)	-0.01100237