IARS1 (Gene)

Ensembl Gene ID: ENSG00000196305

Entrez Gene ID: 3376

Description: isoleucyl-tRNA synthetase 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View IARS1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with IARS1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using IARS1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for IARS1.

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Gene Sets (1041)

ARCHS4 IDG Coexp (9)

A gene set library provided by IDG

rummageo gene perturbations (300)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (291)

A gene set library provided by LINCS

rummageo chemical perturbations (441)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
R-112 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.009699583
SID11111688 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.0030223418
phloretin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.005191433
PI-103 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	-0.005907897
SID-26681509 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.0043593072
treprostinil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	-0.0109729385
Sorafenib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.0057029757
IARS1 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate Metabolite (Entity type)
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.0045368387
N-{4-[4-(4'-Chloro-biphenyl-2-ylmethyl)-piperazin-1-yl]-benzoyl}-4-((S)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-nitro-benzenesulfonamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IARS1 Gene (Entity type)	0.005528625

R-112
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.009699583

SID11111688
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.0030223418

phloretin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.005191433

PI-103
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
-0.005907897

SID-26681509
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.0043593072

treprostinil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
-0.0109729385

Sorafenib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.0057029757

IARS1
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
Metabolite (Entity type)

1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.0045368387

N-{4-[4-(4'-Chloro-biphenyl-2-ylmethyl)-piperazin-1-yl]-benzoyl}-4-((S)-3-dimethylamino-1-phenylsulfanylmethyl-propylamino)-3-nitro-benzenesulfonamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IARS1
Gene (Entity type)
0.005528625

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.