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HMGB2 (Gene)

Ensembl Gene ID: ENSG00000164104

Entrez Gene ID: 3148

Description: high mobility group box 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HMGB2's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HMGB2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HMGB2.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HMGB2.

Gene Sets (3290)

LINCS L1000 Chem Pert Consensus Sigs (811)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (869)

A gene set library provided by LINCS

rummageo gene perturbations (243)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (888)

A gene set library provided by LINCS

rummageo chemical perturbations (475)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	SID11113667 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.0072314315
	VU-0415556-1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	-0.012785378
	docosatrienoic-acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.0091676125
	Necrostatin-1 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.0042584427
	N-(2-methyl-5-(2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.0074896975
	Lisuride Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.007876591
	3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.0050118635
	ethyl 6-(4-(benzylsulfonylcarbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.016645798
	Liver_L2_mature NK T cell:proliferating Anatomy (Entity type)	Has marker gene in liver Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)
	Procarbazine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGB2 Gene (Entity type)	0.003329307

SID11113667
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.0072314315

VU-0415556-1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
-0.012785378

docosatrienoic-acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.0091676125

Necrostatin-1
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.0042584427

N-(2-methyl-5-(2-oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.0074896975

Lisuride
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.007876591

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.0050118635

ethyl 6-(4-(benzylsulfonylcarbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.016645798

Liver_L2_mature NK T cell:proliferating
Anatomy (Entity type)
Has marker gene in liver
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)

Procarbazine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGB2
Gene (Entity type)
0.003329307

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

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