TLK2 (Gene)

Entrez Gene ID: 11011

Description: tousled like kinase 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TLK2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TLK2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TLK2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TLK2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TLK2.

Gene Sets (2201)

LINCS L1000 Chem Pert Consensus Sigs (554)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (3)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (470)

A gene set library provided by LINCS

rummageo gene perturbations (132)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (281)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (582)

A gene set library provided by LINCS

rummageo chemical perturbations (174)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

IDG Drug Targets 2022 (3)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
KFGENEBIN:TLK2-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)
Paromomycin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	-0.019637536
SA-1459261 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	-0.012398184
Cephalexin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	0.0099127935
SA-1455884 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	0.014037537
remimazolam Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	-0.0058752783
acetylsalicylsalicylic-acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	0.008092288
Cyanopindolol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	0.007354265
tiagabine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	-0.0030987936
SA-102695 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TLK2 Gene (Entity type)	-0.024453668

KFGENEBIN:TLK2-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)

Paromomycin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
-0.019637536

SA-1459261
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
-0.012398184

Cephalexin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
0.0099127935

SA-1455884
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
0.014037537

remimazolam
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
-0.0058752783

acetylsalicylsalicylic-acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
0.008092288

Cyanopindolol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
0.007354265

tiagabine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
-0.0030987936

SA-102695
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TLK2
Gene (Entity type)
-0.024453668

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.