ITPKB (Gene)

Entrez Gene ID: 3707

Description: inositol-trisphosphate 3-kinase B

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ITPKB's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ITPKB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ITPKB.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ITPKB.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ITPKB.

Gene Sets (1806)

LINCS L1000 Chem Pert Consensus Sigs (295)

A gene set library provided by LINCS

Metabolomics Workbench Metabolites 2022 (3)

A gene set library provided by MW

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (205)

A gene set library provided by LINCS

rummageo gene perturbations (180)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (384)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (472)

A gene set library provided by LINCS

rummageo chemical perturbations (256)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (6)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	atp binding Metabolite (Entity type)
kitasamycin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	-0.012232083
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	ATP Metabolite (Entity type)
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Inositol 1,3,4,5-tetraphosphate Metabolite (Entity type)
biochanin-a Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	0.010454622
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	ADP Metabolite (Entity type)
AVA Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	0.00631606
KFGENEBIN:ITPKB-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester Metabolite (Entity type)
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Inositol 1,4,5-Trisphosphate Metabolite (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
atp binding
Metabolite (Entity type)

kitasamycin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
-0.012232083

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
ATP
Metabolite (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Inositol 1,3,4,5-tetraphosphate
Metabolite (Entity type)

biochanin-a
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
0.010454622

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
ADP
Metabolite (Entity type)

AVA
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
0.00631606

KFGENEBIN:ITPKB-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester
Metabolite (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Inositol 1,4,5-Trisphosphate
Metabolite (Entity type)

DISPLAY PER PAGE

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
Loading results...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.