ITPKB (Gene)

Entrez Gene ID: 3707

Description: inositol-trisphosphate 3-kinase B

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ITPKB's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ITPKB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ITPKB.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ITPKB.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ITPKB.

Gene Sets (511)

LINCS L1000 Chem Pert Consensus Sigs (295)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (205)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (6)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Adenosine Diphosphate Metabolite (Entity type)
kitasamycin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	-0.012232083
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester Metabolite (Entity type)
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	ADP Metabolite (Entity type)
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Inositol 1,3,4,5-tetraphosphate Metabolite (Entity type)
biochanin-a Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	0.010454622
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	atp binding Metabolite (Entity type)
AVA Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)	0.00631606
ITPKB Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Inositol 1,4,5-Trisphosphate Metabolite (Entity type)
KFGENEBIN:ITPKB-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	ITPKB Gene (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Adenosine Diphosphate
Metabolite (Entity type)

kitasamycin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
-0.012232083

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester
Metabolite (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
ADP
Metabolite (Entity type)

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Inositol 1,3,4,5-tetraphosphate
Metabolite (Entity type)

biochanin-a
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
0.010454622

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
atp binding
Metabolite (Entity type)

AVA
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)
0.00631606

ITPKB
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Inositol 1,4,5-Trisphosphate
Metabolite (Entity type)

KFGENEBIN:ITPKB-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
ITPKB
Gene (Entity type)

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.