HMGCL (Gene)

Entrez Gene ID: 3155

Description: 3-hydroxy-3-methylglutaryl-CoA lyase

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HMGCL's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with HMGCL.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HMGCL.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HMGCL.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HMGCL.

Gene Sets (662)

LINCS L1000 Chem Pert Consensus Sigs (65)

A gene set library provided by LINCS

Metabolomics Workbench Metabolites 2022 (2)

A gene set library provided by MW

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (20)

A gene set library provided by LINCS

rummageo gene perturbations (107)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (281)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (22)

A gene set library provided by LINCS

rummageo chemical perturbations (160)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target
HMGCL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	acetic acid Metabolite (Entity type)
HMGCL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	acetyl coenzyme A Metabolite (Entity type)
HMGCL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	3-Hydroxy-3-methylglutaryl-CoA Metabolite (Entity type)
HMGCL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Acetic Acid Metabolite (Entity type)
HMGCL Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Acetoacetic acid Metabolite (Entity type)
KFGENEBIN:HMGCL-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	HMGCL Gene (Entity type)

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.