TPO (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:7173, HGNC:12015, MIM:606765, MSA, NM_000547, NM_001206744, NM_001206745, NM_175719, NM_175720, NM_175721, NM_175722, NP_000538, NP_001193673, NP_001193674, NP_783650, NP_783652, NP_783653, TDH2A, TPO, TPX, XM_011510380, XM_024453085, XM_024453086, XM_024453087, XM_024453088, XM_024453089, XM_024453090, XM_024453091, XM_024453092, XM_024453093, XP_011508682, XP_024308853, XP_024308854, XP_024308855, XP_024308856, XP_024308857, XP_024308858, XP_024308859, XP_024308860, XP_024308861, thyroid peroxidase

Omim:OMIM:606765

Nci:C26530

Id:ENSG00000115705

Hgnc:HGNC:12015

Entrez:7173

Ensembl:ENSG00000115705

Description:thyroid peroxidase

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TPO's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TPO.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TPO.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TPO.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TPO.

Results found

Linked to

	Label	Description
	GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 11 v 12 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE57871 vorinostat HCT 116 11 v 12 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE57871 11 V 12 VORINOSTAT HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE108464 AZ-628 1 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 cytarabine U2OS 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	Sensorineural hearing impairment Phenotype (Entity type)	A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...
	GSE115384 CELSR2 knockdown 5 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120214 GSE133308 TBXT brachyury inhibition 0 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE171837 bortezomib 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 1 V 2 CYTARABINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 11 v 12 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE57871 vorinostat HCT 116 11 v 12 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE57871 11 V 12 VORINOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE108464 AZ-628 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 cytarabine U2OS 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Sensorineural hearing impairment

Phenotype (Entity type)

A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

GSE115384 CELSR2 knockdown 5 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE120214 GSE133308 TBXT brachyury inhibition 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE171837 bortezomib 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 1 V 2 CYTARABINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.