PLCB4 (Gene)

Entrez Gene ID: 5332

Description: phospholipase C beta 4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PLCB4's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PLCB4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PLCB4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PLCB4.

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Gene Sets (2304)

LINCS L1000 Chem Pert Consensus Sigs (479)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (13)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (593)

A gene set library provided by LINCS

rummageo gene perturbations (187)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (717)

A gene set library provided by LINCS

rummageo chemical perturbations (312)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	0.018314017
AEG-3482 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	-0.0069897366
Racecadotril Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	0.004069316
Talampanel Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	-0.0056891562
2-[4-(3-Dibenzo[b,f]azepin-5-yl-propyl)-piperazin-1-yl]-ethanol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	0.0046098777
Temocapril Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	-0.0045979097
PLCB4 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Inositol 1,4,5-Trisphosphate Metabolite (Entity type)
PLCB4 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	PI 16:0/16:0 Metabolite (Entity type)
4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLCB4 Gene (Entity type)	-0.0058534453
PLCB4 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester Metabolite (Entity type)

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
0.018314017

AEG-3482
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
-0.0069897366

Racecadotril
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
0.004069316

Talampanel
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
-0.0056891562

2-[4-(3-Dibenzo[b,f]azepin-5-yl-propyl)-piperazin-1-yl]-ethanol
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
0.0046098777

Temocapril
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
-0.0045979097

PLCB4
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Inositol 1,4,5-Trisphosphate
Metabolite (Entity type)

PLCB4
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
PI 16:0/16:0
Metabolite (Entity type)

4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLCB4
Gene (Entity type)
-0.0058534453

PLCB4
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
Phosphoric acid mono-((1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4,6-bis-phosphonooxy-cyclohexyl) ester
Metabolite (Entity type)

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.