NOS3 (Gene)

Description: nitric oxide synthase 3

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View NOS3's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with NOS3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using NOS3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for NOS3.

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Gene Sets (168)

LINCS L1000 Chem Pert Consensus Sigs (106)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (1)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (19)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (23)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (5)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (11)

A gene set library provided by GTEx

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NOS3 Gene (Entity type)	0.0060636927
Mitiglinide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOS3 Gene (Entity type)	-0.0049749548
NOS3 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	L-arginine Metabolite (Entity type)
KFGENEBIN:NOS3-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	NOS3 Gene (Entity type)
ST-057710 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOS3 Gene (Entity type)	-0.0120462
NOS3 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	citrulline Metabolite (Entity type)
NOS3 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	L-citrulline Metabolite (Entity type)
Chlorcyclizine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NOS3 Gene (Entity type)	-0.017578077
NOS3 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	arginine Metabolite (Entity type)
NOS3 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	NADP Metabolite (Entity type)