SPEN (Gene)

Description: spen family transcriptional repressor

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SPEN's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SPEN.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SPEN.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SPEN.

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Gene Sets (749)

LINCS L1000 Chem Pert Consensus Sigs (375)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (4)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (2)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (368)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
H-7 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	0.006993309
SID11112767 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	0.0041735535
2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine::2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]thiazepine(clothiapine)::2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine::CHEMBL304902::Clothiapine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	-0.02386918
K-02288 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	-0.00679106
idoxuridin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	-0.0037461838
imiloxan Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	-0.004121094
PK 11195 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)	0.003208844
KFGENEBIN:SPEN-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	SPEN Gene (Entity type)