SHB (Gene)

Description: SH2 domain containing adaptor protein B

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SHB's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SHB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SHB.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SHB.

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Gene Sets (1039)

LINCS L1000 Chem Pert Consensus Sigs (699)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (339)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
ABT-639 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	-0.0044493214
KFGENEBIN:SHB-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)
N,N''-Bis-[1-(3-fluoro-phenyl)-meth-(E)-ylidene]-hydrazine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	0.0056429193
ST-014147 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	0.012761231
L-701252 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	-0.0060151233
Chlorothiazide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	-0.022858674
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraen-1-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	-0.0070545813
SID11111390 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	-0.010244094
AMN-082 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	0.007553374
Mesna Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHB Gene (Entity type)	0.011352629