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GTPase KRas (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View GTPase KRas 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	2-((6S,9S,12S,15S,18S,21S,23aS,29R,37R,40S,42aS)-29-((6S,9S,12S,15S)-6-acetamido-1-amino-9,12,15-tris(3-guanidinopropyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecanamido)-15-sec-butyl-37-((6S,9S,12S,15S)-1,18-diamino-6-carbamoyl-9,12-bis(3-guanidinopropyl)-1-imino-8,11,14-trioxo-2,7,10,13-tetraazaoctadecan-15-ylcarbamoyl)-9,18-bis(4-hydroxybenzyl)-12-(hydroxymethyl)-21-isobutyl-40-isopropyl-5,8,11,14,17,20,23,28,39,42-decaoxotetracontahydrodipyrrolo[2,1-d'1:2',1'-i][1,35,4,7,10,13,16,19,22,25,28,31]dithiadecaazacyclooctatriacontin-6-yl)acetic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-1-(2-ethyl-6-methylphenyl)-7-(2-fluoro-6-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-1-(4,6-diisopropylpyrimidin-5-yl)-7-(2-fluoro-6-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	2-((6S,9S,12S,15S,18S,21S,23aS,29R,34R,37S,39aS)-29-((6S,9S,12R,15S)-6-acetamido-1-amino-9,12,15-tris(3-guanidinopropyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecanamido)-15-sec-butyl-34-((6S,9S,12S,15S)-1,20-diamino-6-carbamoyl-9,12-bis(3-guanidinopropyl)-1,20-diimino-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-ylcarbamoyl)-9,18-bis(4-hydroxybenzyl)-12-(hydroxymethyl)-21-isobutyl-37-isopropyl-5,8,11,14,17,20,23,28,36,39-decaoxohexatriacontahydro-1H-dipyrrolo[2,1-e'1:2',1'-j][1,2,5,8,11,14,17,20,23,26,29,32]dithiadecaazacyclopentatriacontin-6-yl)acetic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	3-((3R,7S,10S,13S,16S,19S,22S,25S,36aS)-13-(4-fluorobenzyl)-10,19,22-tris(3-guanidinopropyl)-16-(4-hydroxybenzyl)-25-isobutyl-29,29-dimethyl-1,5,8,11,14,17,20,23,26,30,31-undecaoxo-3-phenethyltetratriacontahydro-1H-pyrido[2,1-b1][1,4,7,10,13,16,19,22,26,29]oxanonaazacyclotritriacontin-7-yl)propanamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	N-(1-acryloylazetidin-3-yl)-2-(5-chloro-3-(5-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-2,7-dimethyl-1H-indol-1-yl)acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	1-((4aS)-11-chloro-10-(5-methyl-1H-indazol-4-yl)-1,2,4a,5-tetrahydropyrazino[1',2':4,5][1,4]oxazino[2,3-c]quinolin-3(4H)-yl)prop-2-en-1-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	(R)-(S)-4-(4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-7-(2-chlorophenyl)-1-(2-isopropylphenyl)quinazolin-2(1H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	1-[(S)-6-Chloro-2-(2-dimethylamino-ethylamino)-5-(5-methyl-1H-indazol-4-yl)-8a,9,11,12-tetrahydro-8H-7-oxa-1,3,10,12a-tetraaza-benzo[4,5]cyclohepta[1,2,3-de]naphthalen-10-yl]-propenone Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	IC50
	[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]-2-(prop-2-enoylamino)ethyl hydrogen phosphate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	GTPase KRas Protein (Entity type)	Ki

2-((6S,9S,12S,15S,18S,21S,23aS,29R,37R,40S,42aS)-29-((6S,9S,12S,15S)-6-acetamido-1-amino-9,12,15-tris(3-guanidinopropyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecanamido)-15-sec-butyl-37-((6S,9S,12S,15S)-1,18-diamino-6-carbamoyl-9,12-bis(3-guanidinopropyl)-1-imino-8,11,14-trioxo-2,7,10,13-tetraazaoctadecan-15-ylcarbamoyl)-9,18-bis(4-hydroxybenzyl)-12-(hydroxymethyl)-21-isobutyl-40-isopropyl-5,8,11,14,17,20,23,28,39,42-decaoxotetracontahydrodipyrrolo[2,1-d'1:2',1'-i][1,35,4,7,10,13,16,19,22,25,28,31]dithiadecaazacyclooctatriacontin-6-yl)acetic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-1-(2-ethyl-6-methylphenyl)-7-(2-fluoro-6-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-1-(4,6-diisopropylpyrimidin-5-yl)-7-(2-fluoro-6-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

2-((6S,9S,12S,15S,18S,21S,23aS,29R,34R,37S,39aS)-29-((6S,9S,12R,15S)-6-acetamido-1-amino-9,12,15-tris(3-guanidinopropyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecanamido)-15-sec-butyl-34-((6S,9S,12S,15S)-1,20-diamino-6-carbamoyl-9,12-bis(3-guanidinopropyl)-1,20-diimino-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-ylcarbamoyl)-9,18-bis(4-hydroxybenzyl)-12-(hydroxymethyl)-21-isobutyl-37-isopropyl-5,8,11,14,17,20,23,28,36,39-decaoxohexatriacontahydro-1H-dipyrrolo[2,1-e'1:2',1'-j][1,2,5,8,11,14,17,20,23,26,29,32]dithiadecaazacyclopentatriacontin-6-yl)acetic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

3-((3R,7S,10S,13S,16S,19S,22S,25S,36aS)-13-(4-fluorobenzyl)-10,19,22-tris(3-guanidinopropyl)-16-(4-hydroxybenzyl)-25-isobutyl-29,29-dimethyl-1,5,8,11,14,17,20,23,26,30,31-undecaoxo-3-phenethyltetratriacontahydro-1H-pyrido[2,1-b1][1,4,7,10,13,16,19,22,26,29]oxanonaazacyclotritriacontin-7-yl)propanamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

N-(1-acryloylazetidin-3-yl)-2-(5-chloro-3-(5-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-2,7-dimethyl-1H-indol-1-yl)acetamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

1-((4aS)-11-chloro-10-(5-methyl-1H-indazol-4-yl)-1,2,4a,5-tetrahydropyrazino[1',2':4,5][1,4]oxazino[2,3-c]quinolin-3(4H)-yl)prop-2-en-1-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

(R)-(S)-4-(4-Acryloyl-2-methylpiperazin-1-yl)-6-chloro-7-(2-chlorophenyl)-1-(2-isopropylphenyl)quinazolin-2(1H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

1-[(S)-6-Chloro-2-(2-dimethylamino-ethylamino)-5-(5-methyl-1H-indazol-4-yl)-8a,9,11,12-tetrahydro-8H-7-oxa-1,3,10,12a-tetraaza-benzo[4,5]cyclohepta[1,2,3-de]naphthalen-10-yl]-propenone
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
IC50

[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]-2-(prop-2-enoylamino)ethyl hydrogen phosphate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
GTPase KRas
Protein (Entity type)
Ki

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