Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(5S,11aS)-2-Ethyl-5-(5-ethylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
(R)-3-(5-Ethylfuran-2-yl)-2-(5-(pyridin-2-yl)pyrimidin-2-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]quinolin-9-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
3-(5-ethylfuran-2-yl)-2-(5-(pyridin-2-yl)pyrimidin-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-9(4H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
(5R,11aR)-2-Ethyl-5-(5-ethylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
(5S,11aS)-2-Ethyl-5-(5-methylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
(6S,12aR)-6-(5-Bromothiophen-2-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
N-(3-(5,6-Diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50
4-Ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' Protein (Entity type)	IC50

(5S,11aS)-2-Ethyl-5-(5-ethylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

(R)-3-(5-Ethylfuran-2-yl)-2-(5-(pyridin-2-yl)pyrimidin-2-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]quinolin-9-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

3-(5-ethylfuran-2-yl)-2-(5-(pyridin-2-yl)pyrimidin-2-yl)-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-9(4H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

(5R,11aR)-2-Ethyl-5-(5-ethylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

(5S,11aS)-2-Ethyl-5-(5-methylfuran-2-yl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

(6S,12aR)-6-(5-Bromothiophen-2-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

N-(3-(5,6-Diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

4-Ethoxy-N-(6-hydroxyhexyl)-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Protein (Entity type)
IC50

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