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Melanocortin receptor 5 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Melanocortin receptor 5 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	IC50
	(S)-2-((R)-2-((S)-4-acetamido-3-oxo-4,5-dihydroazepino[3,4-b]indol-2(1H,3H,10H)-yl)-3-(4-bromophenyl)propanamido)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	IC50
	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	EC50
	(2S)-N-[(1S)-2-[[(2S)-2-amino-3-[[(1S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-12-carbamoyl-18-(3-guanidinopropyl)-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]carbamoyl]pentyl]amino]-3-oxo-propyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-2-[[(2S)-3-hydroxy-2-[[2-[[2-[2-[2-[16-(1H-tetrazol-5-yl)hexadecanoylamino]ethoxy]ethoxy]acetyl]amino]acetyl]amino]propanoyl]amino]pentanediamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	Ki
	(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-18-(3-guanidinopropyl)-3-[[(2S)-2-[[2-[[2-[[2-[[2-[[2-(hexadecanoylamino)acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosane-12-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	Ki
	1-[(R)-2-[((1R,2R)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	IC50
	(S)-2-((R)-2-((S)-4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]azepin-2(3H)-yl)-3-phenylpropanamido)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	IC50
	4-[(4-Benzyl-N-cyclohexyl-piperazine-1-carboximidoyl)-amino]-N-[2-(2,4-dichloro-phenyl)-ethyl]-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	Ki
	H-Tyr-Val-Leu-Gly-Pro-Phe-Leu-Trp-Asp-Arg-Phe-Gly-NH2 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	IC50
	(2S)-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-12-carbamoyl-18-(3-guanidinopropyl)-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-2-[[(2S)-3-hydroxy-2-[[2-[[2-[2-[2-[16-(1H-tetrazol-5-yl)hexadecanoylamino]ethoxy]ethoxy]acetyl]amino]acetyl]amino]propanoyl]amino]pentanediamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Melanocortin receptor 5 Protein (Entity type)	Ki

1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
IC50

(S)-2-((R)-2-((S)-4-acetamido-3-oxo-4,5-dihydroazepino[3,4-b]indol-2(1H,3H,10H)-yl)-3-(4-bromophenyl)propanamido)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
IC50

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
EC50

(2S)-N-[(1S)-2-[[(2S)-2-amino-3-[[(1S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-12-carbamoyl-18-(3-guanidinopropyl)-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]carbamoyl]pentyl]amino]-3-oxo-propyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-2-[[(2S)-3-hydroxy-2-[[2-[[2-[2-[2-[16-(1H-tetrazol-5-yl)hexadecanoylamino]ethoxy]ethoxy]acetyl]amino]acetyl]amino]propanoyl]amino]pentanediamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
Ki

(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-18-(3-guanidinopropyl)-3-[[(2S)-2-[[2-[[2-[[2-[[2-[[2-(hexadecanoylamino)acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosane-12-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
Ki

1-[(R)-2-[((1R,2R)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
IC50

(S)-2-((R)-2-((S)-4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]azepin-2(3H)-yl)-3-phenylpropanamido)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
IC50

4-[(4-Benzyl-N-cyclohexyl-piperazine-1-carboximidoyl)-amino]-N-[2-(2,4-dichloro-phenyl)-ethyl]-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
Ki

H-Tyr-Val-Leu-Gly-Pro-Phe-Leu-Trp-Asp-Arg-Phe-Gly-NH2
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
IC50

(2S)-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-12-carbamoyl-18-(3-guanidinopropyl)-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-2-[[(2S)-3-hydroxy-2-[[2-[[2-[2-[2-[16-(1H-tetrazol-5-yl)hexadecanoylamino]ethoxy]ethoxy]acetyl]amino]acetyl]amino]propanoyl]amino]pentanediamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Melanocortin receptor 5
Protein (Entity type)
Ki

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