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Interleukin-23 receptor (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Interleukin-23 receptor 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	(3S,6S,9S,12R,15S,18S,21S,24S,27S,39R)-6,18-bis((1H-indol-3-yl)methyl)-3-((S)-2-((R)-2-acetamido-3-mercaptopropanamido)-5-amino-5-oxopentanamido)-43-amino-9-(3-amino-3-oxopropyl)-27-benzyl-39-carbamoyl-21-(3-guanidinopropyl)-15-(4-hydroxybenzyl)-12-(mercaptomethyl)-24-octyl-4,7,10,13,16,19,22,25,28,31,37-undecaoxo-35-oxa-5,8,11,14,17,20,23,26,29,32,38-undecaazatritetracontan-1-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(4R,7S,10S,13S,16S,19R,22S,25S,28S,31S,34S,40S,43S,46S)-7-((1H-imidazol-5-yl)methyl)-13,25-bis((1H-indol-3-yl)methyl)-31-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-34-benzyl-46-carbamoyl-43-(2-carboxyethyl)-40-(carboxymethyl)-22-(4-hydroxybenzyl)-10-((R)-1-hydroxyethyl)-28-isobutyl-4,19-bis(mercaptomethyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-pentadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-pentadecaazanonatetracontan-49-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(S)-2-((3S,6S,9S,12S)-1-((3R,6S,9S,12S,15S,18S)-9-((1H-indol-3-yl)methyl)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-9-(4-aminobutyl)-12-isopropyl-3-(4-methoxybenzyl)-9-methyl-6-(naphthalen-2-ylmethyl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecanamido)-N1-(2-amino-2-oxoethyl)succinamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(3S,6S,9S,12S)-1-((3R,6S,9S,12S,15S,18S)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-9-((6-chloro-1H-indol-3-yl)methyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-12-((S)-4-amino-1-(2-amino-2-oxoethylamino)-1,4-dioxobutan-2-ylcarbamoyl)-9-(4-aminobutyl)-3-(4-(2-aminoethoxy)benzyl)-9-methyl-6-(naphthalen-2-ylmethyl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(S)-N1-((5S,8S,11S,14S,17S,20R)-14-((1H-indol-3-yl)methyl)-1-amino-5-(2-amino-2-oxoethyl)-17-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-11-isopentyl-21-mercapto-1,4,7,10,13,16,19-heptaoxo-3,6,9,12,15,18-hexaazahenicosan-20-yl)-2-((2S,5S,8S,11R)-2-((1H-indol-3-yl)methyl)-8-(3-amino-3-oxopropyl)-5-((R)-1-hydroxyethyl)-11-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)pentanediamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(3S,6S,12S)-6-((1H-indol-3-yl)methyl)-1-((3R,6S,9S,12S,15S,18S)-9-((1H-indol-3-yl)methyl)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-12-((S)-4-amino-1-(2-amino-2-oxoethylamino)-1,4-dioxobutan-2-ylcarbamoyl)-3-(4-(2-aminoethoxy)benzyl)-9,9-dimethyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(5S,8S,11S,14S,17S,20R,23S,26S,29S)-11-((1H-imidazol-5-yl)methyl)-14,26-bis((1H-indol-3-yl)methyl)-29-((S)-2-((R)-2-acetamido-3-mercapto-3-methylbutanamido)propanamido)-1-amino-5-benzyl-17-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-23-isopropyl-20-(mercaptomethyl)-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-31-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(S)-N1-((2R,5S,8S,11S,14S,17S,29R)-8-((1H-indol-3-yl)methyl)-33-amino-17-benzyl-29-carbamoyl-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-14-isopropyl-1-mercapto-3,6,9,12,15,18,21,27-octaoxo-25-oxa-4,7,10,13,16,19,22,28-octaazatritriacontan-2-yl)-2-((2S,5S,8S,11R)-2-((1H-indol-3-yl)methyl)-8-(2-amino-2-oxoethyl)-5-((R)-1-hydroxyethyl)-11-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)pentanediamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(S)-N-((5S,8S,11S,14S,17S,20R,23S,26S,29S,30R)-11-((1H-imidazol-5-yl)methyl)-14,26-bis((1H-indol-3-yl)methyl)-1-amino-30-hydroxy-5,17-bis(4-hydroxybenzyl)-8,23-bis((R)-1-hydroxyethyl)-20-(mercaptomethyl)-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-29-yl)-2-((R)-2-acetamido-3-mercaptopropanamido)-6-aminohexanamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50
	(4R,7S,10S,13S,16S,19R,22S,25S,28S,31S,34S,40S,43S)-13,25-bis((1H-indol-3-yl)methyl)-16-(3-amino-3-oxopropyl)-31-(4-aminobutyl)-34-benzyl-43-((S)-2-carbamoylpyrrolidine-1-carbonyl)-7-(3-guanidinopropyl)-22-(4-hydroxybenzyl)-10,28-bis((R)-1-hydroxyethyl)-40-(hydroxymethyl)-4,19-bis(mercaptomethyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41-tetradecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaazahexatetracontan-46-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Interleukin-23 receptor Protein (Entity type)	IC50

(3S,6S,9S,12R,15S,18S,21S,24S,27S,39R)-6,18-bis((1H-indol-3-yl)methyl)-3-((S)-2-((R)-2-acetamido-3-mercaptopropanamido)-5-amino-5-oxopentanamido)-43-amino-9-(3-amino-3-oxopropyl)-27-benzyl-39-carbamoyl-21-(3-guanidinopropyl)-15-(4-hydroxybenzyl)-12-(mercaptomethyl)-24-octyl-4,7,10,13,16,19,22,25,28,31,37-undecaoxo-35-oxa-5,8,11,14,17,20,23,26,29,32,38-undecaazatritetracontan-1-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(4R,7S,10S,13S,16S,19R,22S,25S,28S,31S,34S,40S,43S,46S)-7-((1H-imidazol-5-yl)methyl)-13,25-bis((1H-indol-3-yl)methyl)-31-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-34-benzyl-46-carbamoyl-43-(2-carboxyethyl)-40-(carboxymethyl)-22-(4-hydroxybenzyl)-10-((R)-1-hydroxyethyl)-28-isobutyl-4,19-bis(mercaptomethyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-pentadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-pentadecaazanonatetracontan-49-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(S)-2-((3S,6S,9S,12S)-1-((3R,6S,9S,12S,15S,18S)-9-((1H-indol-3-yl)methyl)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-9-(4-aminobutyl)-12-isopropyl-3-(4-methoxybenzyl)-9-methyl-6-(naphthalen-2-ylmethyl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecanamido)-N1-(2-amino-2-oxoethyl)succinamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(3S,6S,9S,12S)-1-((3R,6S,9S,12S,15S,18S)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-9-((6-chloro-1H-indol-3-yl)methyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-12-((S)-4-amino-1-(2-amino-2-oxoethylamino)-1,4-dioxobutan-2-ylcarbamoyl)-9-(4-aminobutyl)-3-(4-(2-aminoethoxy)benzyl)-9-methyl-6-(naphthalen-2-ylmethyl)-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(S)-N1-((5S,8S,11S,14S,17S,20R)-14-((1H-indol-3-yl)methyl)-1-amino-5-(2-amino-2-oxoethyl)-17-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-11-isopentyl-21-mercapto-1,4,7,10,13,16,19-heptaoxo-3,6,9,12,15,18-hexaazahenicosan-20-yl)-2-((2S,5S,8S,11R)-2-((1H-indol-3-yl)methyl)-8-(3-amino-3-oxopropyl)-5-((R)-1-hydroxyethyl)-11-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)pentanediamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(3S,6S,12S)-6-((1H-indol-3-yl)methyl)-1-((3R,6S,9S,12S,15S,18S)-9-((1H-indol-3-yl)methyl)-18-acetamido-6,15-bis(3-amino-3-oxopropyl)-12-((R)-1-hydroxyethyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl)-12-((S)-4-amino-1-(2-amino-2-oxoethylamino)-1,4-dioxobutan-2-ylcarbamoyl)-3-(4-(2-aminoethoxy)benzyl)-9,9-dimethyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(5S,8S,11S,14S,17S,20R,23S,26S,29S)-11-((1H-imidazol-5-yl)methyl)-14,26-bis((1H-indol-3-yl)methyl)-29-((S)-2-((R)-2-acetamido-3-mercapto-3-methylbutanamido)propanamido)-1-amino-5-benzyl-17-(4-hydroxybenzyl)-8-((R)-1-hydroxyethyl)-23-isopropyl-20-(mercaptomethyl)-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-31-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(S)-N1-((2R,5S,8S,11S,14S,17S,29R)-8-((1H-indol-3-yl)methyl)-33-amino-17-benzyl-29-carbamoyl-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-14-isopropyl-1-mercapto-3,6,9,12,15,18,21,27-octaoxo-25-oxa-4,7,10,13,16,19,22,28-octaazatritriacontan-2-yl)-2-((2S,5S,8S,11R)-2-((1H-indol-3-yl)methyl)-8-(2-amino-2-oxoethyl)-5-((R)-1-hydroxyethyl)-11-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)pentanediamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(S)-N-((5S,8S,11S,14S,17S,20R,23S,26S,29S,30R)-11-((1H-imidazol-5-yl)methyl)-14,26-bis((1H-indol-3-yl)methyl)-1-amino-30-hydroxy-5,17-bis(4-hydroxybenzyl)-8,23-bis((R)-1-hydroxyethyl)-20-(mercaptomethyl)-1,4,7,10,13,16,19,22,25,28-decaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontan-29-yl)-2-((R)-2-acetamido-3-mercaptopropanamido)-6-aminohexanamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

(4R,7S,10S,13S,16S,19R,22S,25S,28S,31S,34S,40S,43S)-13,25-bis((1H-indol-3-yl)methyl)-16-(3-amino-3-oxopropyl)-31-(4-aminobutyl)-34-benzyl-43-((S)-2-carbamoylpyrrolidine-1-carbonyl)-7-(3-guanidinopropyl)-22-(4-hydroxybenzyl)-10,28-bis((R)-1-hydroxyethyl)-40-(hydroxymethyl)-4,19-bis(mercaptomethyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41-tetradecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaazahexatetracontan-46-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Interleukin-23 receptor
Protein (Entity type)
IC50

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