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Placenta growth factor (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Placenta growth factor 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(2-amino-2-oxoethyl)-6-((5S,8S,11S)-5-carbamoyl-8-isopropyl-7,10,17-trioxo-2-thia-6,9,16-triazaoctadecan-11-ylcarbamoyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(3S,6S,9S,12S,15S)-3-((S)-2-acetamidopropanamido)-12-benzyl-15-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3,14-bis((1H-imidazol-5-yl)methyl)-6-((2R,3R)-1-((R)-1-((R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-20-sec-butyl-17-(4-hydroxybenzyl)-26-isobutyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-6,9,14-trimethyl-4,7,10,13-tetraoxo-5,8,11,14-tetraazaoctadecane-1,18-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	IC50
	(S)-4-((S)-2-acetamido-3-phenylpropanamido)-5-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3,14-bis((1H-imidazol-5-yl)methyl)-6-((2S,3R)-1-((S)-1-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-20-sec-butyl-17-(4-hydroxybenzyl)-26-isobutyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-6-((5S,8S,11S)-5-carbamoyl-8-isopropyl-7,10,17-trioxo-2-thia-6,9,16-triazaoctadecan-11-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxo-14-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(2-amino-2-oxoethyl)-6-((8S,11S,14S)-8-(4-aminobutyl)-11-isopropyl-1,5,7,10,13,20-hexaoxo-1-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)-3-oxa-6,9,12,19-tetraazahenicosan-14-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(3S,6S,9S,12S,15S)-3-((S)-2-acetamidopropanamido)-12-benzyl-15-((S)-1-((4R,7S,13S,16S,19S,22S,25S,28R)-7,25-bis((1H-imidazol-5-yl)methyl)-4-((2R,3R)-1-((S)-6-acetamido-1-(1-amino-2-methyl-1-oxopropan-2-ylamino)-1-oxohexan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-19-sec-butyl-22-(4-hydroxybenzyl)-13-isobutyl-10,10-dimethyl-6,9,12,15,18,21,24,27-octaoxo-16-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosan-28-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-6,9,14-trimethyl-4,7,10,13-tetraoxo-5,8,11,14-tetraazaoctadecane-1,18-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	Geranin B Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(2S)-4',5,7-trihydroxyflavan-(4beta->8)-afzelechin Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-6-((S)-6-amino-1-((S)-1-((S)-1-amino-4-(methylthio)-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-1-oxohexan-2-ylcarbamoyl)-14-(4-aminobutyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-4-oxo-3-((S)-2-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)-3-phenylpropanamido)butanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd
	(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(4-acetamidobutyl)-6-((8S,11S,14S)-8-(4-aminobutyl)-11-isopropyl-1,5,7,10,13,20-hexaoxo-1-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)-3-oxa-6,9,12,19-tetraazahenicosan-14-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Placenta growth factor Protein (Entity type)	Kd

(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(2-amino-2-oxoethyl)-6-((5S,8S,11S)-5-carbamoyl-8-isopropyl-7,10,17-trioxo-2-thia-6,9,16-triazaoctadecan-11-ylcarbamoyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(3S,6S,9S,12S,15S)-3-((S)-2-acetamidopropanamido)-12-benzyl-15-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3,14-bis((1H-imidazol-5-yl)methyl)-6-((2R,3R)-1-((R)-1-((R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-20-sec-butyl-17-(4-hydroxybenzyl)-26-isobutyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-6,9,14-trimethyl-4,7,10,13-tetraoxo-5,8,11,14-tetraazaoctadecane-1,18-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
IC50

(S)-4-((S)-2-acetamido-3-phenylpropanamido)-5-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3,14-bis((1H-imidazol-5-yl)methyl)-6-((2S,3R)-1-((S)-1-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-20-sec-butyl-17-(4-hydroxybenzyl)-26-isobutyl-1,4,12,15,18,21,24,27-octaoxo-23-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-5-oxopentanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-6-((5S,8S,11S)-5-carbamoyl-8-isopropyl-7,10,17-trioxo-2-thia-6,9,16-triazaoctadecan-11-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxo-14-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)octacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(2-amino-2-oxoethyl)-6-((8S,11S,14S)-8-(4-aminobutyl)-11-isopropyl-1,5,7,10,13,20-hexaoxo-1-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)-3-oxa-6,9,12,19-tetraazahenicosan-14-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(3S,6S,9S,12S,15S)-3-((S)-2-acetamidopropanamido)-12-benzyl-15-((S)-1-((4R,7S,13S,16S,19S,22S,25S,28R)-7,25-bis((1H-imidazol-5-yl)methyl)-4-((2R,3R)-1-((S)-6-acetamido-1-(1-amino-2-methyl-1-oxopropan-2-ylamino)-1-oxohexan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-19-sec-butyl-22-(4-hydroxybenzyl)-13-isobutyl-10,10-dimethyl-6,9,12,15,18,21,24,27-octaoxo-16-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosan-28-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-6,9,14-trimethyl-4,7,10,13-tetraoxo-5,8,11,14-tetraazaoctadecane-1,18-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

Geranin B
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(2S)-4',5,7-trihydroxyflavan-(4beta->8)-afzelechin
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-6-((S)-6-amino-1-((S)-1-((S)-1-amino-4-(methylthio)-1-oxobutan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-1-oxohexan-2-ylcarbamoyl)-14-(4-aminobutyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-4-oxo-3-((S)-2-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)-3-phenylpropanamido)butanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

(S)-4-((S)-1-((3S,6R,11R,14S,17S,20S,23S,26S,31aS)-3-((1H-imidazol-5-yl)methyl)-17-((1H-indol-3-yl)methyl)-14-(4-acetamidobutyl)-6-((8S,11S,14S)-8-(4-aminobutyl)-11-isopropyl-1,5,7,10,13,20-hexaoxo-1-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)-3-oxa-6,9,12,19-tetraazahenicosan-14-ylcarbamoyl)-23-((R)-1-hydroxyethyl)-26-isobutyl-20-isopropyl-1,4,12,15,18,21,24,27-octaoxooctacosahydro-1H-pyrrolo[2,1-j][1,2,5,8,11,14,17,20,23,26]dithiaoctaazacyclononacosin-11-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-((S)-2-acetamido-3-phenylpropanamido)-4-oxobutanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Placenta growth factor
Protein (Entity type)
Kd

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