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LIM domain kinase 1 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LIM domain kinase 1 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	SID103904591 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	Ki
	(S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	(S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido)phenyl dimethylcarbamate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	N-{5-[3-(2-Chloro-phenyl)-pyridin-4-yl]-thiazol-2-yl}-isobutyramide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	SID103904402 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	Ki
	methyl 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)benzoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	methyl 3-(1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-((dimethylamino)methyl)piperidine-4-carboxamido)benzoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	compound 31 [PMID: 22902653] Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	1-(4-Chlorophenyl)-3-(4-(5,6-dimethyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-2-fluorophenyl)-1-(2-methoxyethyl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50
	4-(5-(3-(2-chlorophenyl)pyridin-4-yl)thiazol-2-ylamino)phenol Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	LIM domain kinase 1 Protein (Entity type)	IC50

SID103904591
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
Ki

(S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

(S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxamido)phenyl dimethylcarbamate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

N-{5-[3-(2-Chloro-phenyl)-pyridin-4-yl]-thiazol-2-yl}-isobutyramide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

SID103904402
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
Ki

methyl 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)benzoate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

methyl 3-(1-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-((dimethylamino)methyl)piperidine-4-carboxamido)benzoate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

compound 31 [PMID: 22902653]
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

1-(4-Chlorophenyl)-3-(4-(5,6-dimethyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-2-fluorophenyl)-1-(2-methoxyethyl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

4-(5-(3-(2-chlorophenyl)pyridin-4-yl)thiazol-2-ylamino)phenol
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
LIM domain kinase 1
Protein (Entity type)
IC50

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