3-hydroxy-3-methylglutaryl-coenzyme A reductase (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-hydroxy-3-methylglutaryl-coenzyme A reductase 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(E)-6-{2-[6-Cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
sodium (3R,5R)-7-(5-((4-(dimethylcarbamoyl)phenyl)carbamoyl)-3-(4-fluorophenyl)-1-isopropyl-4-phenyl-1H-pyrrol-2-yl)-3,5-dihydroxyheptanoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
(E)-(3R,5S)-7-[4,5-Bis-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
Sodium salt of 7-[4-(4-Fluoro-phenyl)-2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxy-hept-6-enoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
(E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-5-isopropyl-2-phenyl-pyrrol-1-yl]-3,5-dihydroxy-hept-6-enoic acid anion Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester (simvastatin (salt)) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
(R)-((1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl)2-methylbutanoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
Sodium salt of 7-[1-Cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-1H-pyrrol-3-yl]-3,5-dihydroxy-heptanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
Sodium salt 7-[5-(4-fluoro-phenyl)-1-pyridin-2-yl-3-trifluoromethyl-1H-pyrazol-4-yl]-3,5-dihydroxy-hept-6-enoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50
Sodium salt 7-[5-(4-fluoro-phenyl)-3-isopropyl-1-pyridin-2-yl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	3-hydroxy-3-methylglutaryl-coenzyme A reductase Protein (Entity type)	IC50