4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLC35F2 Gene (Entity type)	-0.003981137
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LEF1 Gene (Entity type)	-0.0039978446
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA1 Gene (Entity type)	-0.00464019
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SPRED2 Gene (Entity type)	-0.0034409182
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LSM5 Gene (Entity type)	0.0049024057
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1X Gene (Entity type)	0.0037189603
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KMO Gene (Entity type)	-0.0036388654
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD9 Gene (Entity type)	-0.0048012296
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TXNIP Gene (Entity type)	0.0047802054
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Receptor tyrosine-protein kinase erbB-2 Protein (Entity type)	IC50

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLC35F2
Gene (Entity type)
-0.003981137

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LEF1
Gene (Entity type)
-0.0039978446

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PHLDA1
Gene (Entity type)
-0.00464019

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SPRED2
Gene (Entity type)
-0.0034409182

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LSM5
Gene (Entity type)
0.0049024057

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1X
Gene (Entity type)
0.0037189603

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KMO
Gene (Entity type)
-0.0036388654

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD9
Gene (Entity type)
-0.0048012296

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TXNIP
Gene (Entity type)
0.0047802054

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Receptor tyrosine-protein kinase erbB-2
Protein (Entity type)
IC50

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