8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Asthma Disease or Phenotype (Entity type)
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A8 Gene (Entity type)	0.0038418218
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PTGIS Gene (Entity type)	-0.0036349755
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GABRP Gene (Entity type)	0.0038003314
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AQP1 Gene (Entity type)	0.0038040066
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AMOTL2 Gene (Entity type)	-0.003856267
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DSP Gene (Entity type)	-0.0039412165
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NR4A2 Gene (Entity type)	-0.003478627
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MLLT11 Gene (Entity type)	-0.004201004
8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ecabet Compound (Entity type)	0.3137510120868683

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Asthma
Disease or Phenotype (Entity type)

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A8
Gene (Entity type)
0.0038418218

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PTGIS
Gene (Entity type)
-0.0036349755

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GABRP
Gene (Entity type)
0.0038003314

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AQP1
Gene (Entity type)
0.0038040066

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AMOTL2
Gene (Entity type)
-0.003856267

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DSP
Gene (Entity type)
-0.0039412165

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NR4A2
Gene (Entity type)
-0.003478627

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MLLT11
Gene (Entity type)
-0.004201004

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ecabet
Compound (Entity type)
0.3137510120868683

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