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Roflumilast (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Roflumilast's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Roflumilast Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Dienestrol Compound (Entity type)	0.4511184692382812
	Roflumilast Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PRPF4 Gene (Entity type)	0.005843968
	4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Roflumilast Compound (Entity type)	0.2740573585033417
	Roflumilast Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	lamotrigine Compound (Entity type)	0.4522593021392822
	Roflumilast Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CES1 Gene (Entity type)	-0.0037656417
	Roflumilast Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFIT1 Gene (Entity type)	0.0050516897
	Roflumilast Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LMO2 Gene (Entity type)	0.00411518
	Roflumilast Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	cAMP-specific 3',5'-cyclic phosphodiesterase 4A Protein (Entity type)	IC50
	lamotrigine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Roflumilast Compound (Entity type)	0.4522593021392822
	Roflumilast Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MRPS16 Gene (Entity type)	0.0041054166

Roflumilast
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Dienestrol
Compound (Entity type)
0.4511184692382812

Roflumilast
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PRPF4
Gene (Entity type)
0.005843968

4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Roflumilast
Compound (Entity type)
0.2740573585033417

Roflumilast
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
lamotrigine
Compound (Entity type)
0.4522593021392822

Roflumilast
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CES1
Gene (Entity type)
-0.0037656417

Roflumilast
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFIT1
Gene (Entity type)
0.0050516897

Roflumilast
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LMO2
Gene (Entity type)
0.00411518

Roflumilast
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Protein (Entity type)
IC50

lamotrigine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Roflumilast
Compound (Entity type)
0.4522593021392822

Roflumilast
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MRPS16
Gene (Entity type)
0.0041054166

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