(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1G Gene (Entity type)	0.008744459
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TNFSF10 Gene (Entity type)	-0.008389949
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1H Gene (Entity type)	0.010189439
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	NADH-ubiquinone oxidoreductase chain 4 Protein (Entity type)	IC50
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL10 Gene (Entity type)	-0.0072258497
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1HL1 Gene (Entity type)	0.00873079
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HMGCS1 Gene (Entity type)	-0.009246569
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1E Gene (Entity type)	0.010710454
SID103905586 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	0.2472490221261978
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	dolastatin-10 Compound (Entity type)	0.5488259196281433

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1G
Gene (Entity type)
0.008744459

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TNFSF10
Gene (Entity type)
-0.008389949

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1H
Gene (Entity type)
0.010189439

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
NADH-ubiquinone oxidoreductase chain 4
Protein (Entity type)
IC50

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL10
Gene (Entity type)
-0.0072258497

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1HL1
Gene (Entity type)
0.00873079

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HMGCS1
Gene (Entity type)
-0.009246569

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1E
Gene (Entity type)
0.010710454

SID103905586
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
0.2472490221261978

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
dolastatin-10
Compound (Entity type)
0.5488259196281433

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