2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CLEC11A Gene (Entity type)	0.003975918
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TNFSF10 Gene (Entity type)	-0.0036990866
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	cGMP-specific 3',5'-cyclic phosphodiesterase Protein (Entity type)	IC50
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CA12 Gene (Entity type)	0.004629989
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	0.007000493
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TM4SF1 Gene (Entity type)	-0.0034582026
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HERPUD1 Gene (Entity type)	-0.003462461
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Protein (Entity type)	IC50
Moxidectin Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	0.4792535305023193
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ASS1 Gene (Entity type)	0.004588429

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CLEC11A
Gene (Entity type)
0.003975918

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TNFSF10
Gene (Entity type)
-0.0036990866

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
cGMP-specific 3',5'-cyclic phosphodiesterase
Protein (Entity type)
IC50

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CA12
Gene (Entity type)
0.004629989

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
0.007000493

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TM4SF1
Gene (Entity type)
-0.0034582026

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HERPUD1
Gene (Entity type)
-0.003462461

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein (Entity type)
IC50

Moxidectin
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
0.4792535305023193

2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ASS1
Gene (Entity type)
0.004588429

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