(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LOX Gene (Entity type)	-0.02189636
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ADM Gene (Entity type)	-0.026796198
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RARRES1 Gene (Entity type)	0.030962897
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOX Gene (Entity type)	-0.02064119
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GAB2 Gene (Entity type)	0.022486022
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAGEA3 Gene (Entity type)	0.026569853
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase JAK3 Protein (Entity type)	IC50
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LPAR1 Gene (Entity type)	-0.021849401
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SCRG1 Gene (Entity type)	-0.022403158
(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IKZF1 Gene (Entity type)	-0.034684453

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LOX
Gene (Entity type)
-0.02189636

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ADM
Gene (Entity type)
-0.026796198

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RARRES1
Gene (Entity type)
0.030962897

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOX
Gene (Entity type)
-0.02064119

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GAB2
Gene (Entity type)
0.022486022

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MAGEA3
Gene (Entity type)
0.026569853

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase JAK3
Protein (Entity type)
IC50

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LPAR1
Gene (Entity type)
-0.021849401

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SCRG1
Gene (Entity type)
-0.022403158

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IKZF1
Gene (Entity type)
-0.034684453

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