6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLC7A1 Gene (Entity type)	-0.0043631457
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA1 Gene (Entity type)	-0.0035901791
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAC8 Gene (Entity type)	-0.0038975785
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	BPHL Gene (Entity type)	0.004183229
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ulixertinib Compound (Entity type)	0.3659020364284515
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MGLL Gene (Entity type)	-0.004386696
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MSMO1 Gene (Entity type)	0.0044913236
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	UCHL1 Gene (Entity type)	0.004682311
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CEACAM6 Gene (Entity type)	0.0048462376
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMEM50B Gene (Entity type)	0.0040216185

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLC7A1
Gene (Entity type)
-0.0043631457

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PHLDA1
Gene (Entity type)
-0.0035901791

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAC8
Gene (Entity type)
-0.0038975785

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
BPHL
Gene (Entity type)
0.004183229

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ulixertinib
Compound (Entity type)
0.3659020364284515

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MGLL
Gene (Entity type)
-0.004386696

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MSMO1
Gene (Entity type)
0.0044913236

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
UCHL1
Gene (Entity type)
0.004682311

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CEACAM6
Gene (Entity type)
0.0048462376

6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMEM50B
Gene (Entity type)
0.0040216185

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Knowledge Graph Assertions

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