N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity nerve growth factor receptor Protein (Entity type)	Kd
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proto-oncogene tyrosine-protein kinase ROS Protein (Entity type)	IC50
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Reactive oxygen species 1 positive non-small cell lung cancer Disease or Phenotype (Entity type)
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fer Protein (Entity type)	Ki
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase JAK2 Protein (Entity type)	Ki
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	NT-3 growth factor receptor Protein (Entity type)	Ki
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	BDNF/NT-3 growth factors receptor Protein (Entity type)	Ki
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Solid neoplasm with neurotrophic receptor tyrosine kinase gene fusion Disease or Phenotype (Entity type)
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase FRK Protein (Entity type)	Ki
N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	ALK tyrosine kinase receptor Protein (Entity type)	Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity nerve growth factor receptor
Protein (Entity type)
Kd

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proto-oncogene tyrosine-protein kinase ROS
Protein (Entity type)
IC50

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Reactive oxygen species 1 positive non-small cell lung cancer
Disease or Phenotype (Entity type)

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Fer
Protein (Entity type)
Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase JAK2
Protein (Entity type)
Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
NT-3 growth factor receptor
Protein (Entity type)
Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
BDNF/NT-3 growth factors receptor
Protein (Entity type)
Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Solid neoplasm with neurotrophic receptor tyrosine kinase gene fusion
Disease or Phenotype (Entity type)

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase FRK
Protein (Entity type)
Ki

N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
ALK tyrosine kinase receptor
Protein (Entity type)
Ki

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