3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	OLFML3 Gene (Entity type)	0.0039635655
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GREM1 Gene (Entity type)	0.004454118
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Fibroblast growth factor receptor 1 Protein (Entity type)	IC50
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOSL1 Gene (Entity type)	-0.0044928906
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IGFBP5 Gene (Entity type)	0.0044533964
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Cholangiocarcinoma Disease or Phenotype (Entity type)
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HOXC6 Gene (Entity type)	0.0050714444
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IER3 Gene (Entity type)	-0.0046065054
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GOLGA8A Gene (Entity type)	0.004694519
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NUPR1 Gene (Entity type)	0.004032871

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
OLFML3
Gene (Entity type)
0.0039635655

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GREM1
Gene (Entity type)
0.004454118

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Fibroblast growth factor receptor 1
Protein (Entity type)
IC50

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOSL1
Gene (Entity type)
-0.0044928906

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IGFBP5
Gene (Entity type)
0.0044533964

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Cholangiocarcinoma
Disease or Phenotype (Entity type)

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HOXC6
Gene (Entity type)
0.0050714444

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IER3
Gene (Entity type)
-0.0046065054

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GOLGA8A
Gene (Entity type)
0.004694519

3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-{6-4-(4-ethylpiperazin-1-yl)phenylamino-pyrimidin-4-yl}-1-methyl-urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NUPR1
Gene (Entity type)
0.004032871

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