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methotrexate (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View methotrexate's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	methotrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DLGAP5 Gene (Entity type)	-0.009364117
	methotrexate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	clofarabine Compound (Entity type)	0.5219258069992065
	methotrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ASPM Gene (Entity type)	-0.008950212
	methotrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCN2 Gene (Entity type)	0.008277596
	Fluorouracil Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	methotrexate Compound (Entity type)	0.3902971744537353
	5-(4-Chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	methotrexate Compound (Entity type)	0.4252593517303467
	methotrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	BUB1 Gene (Entity type)	-0.008435287
	methotrexate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCDH9 Gene (Entity type)	-0.008600152
	methotrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	F2RL1 Gene (Entity type)	0.0096849715
	methotrexate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ATF3 Gene (Entity type)	0.011475772

methotrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DLGAP5
Gene (Entity type)
-0.009364117

methotrexate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
clofarabine
Compound (Entity type)
0.5219258069992065

methotrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ASPM
Gene (Entity type)
-0.008950212

methotrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCN2
Gene (Entity type)
0.008277596

Fluorouracil
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
methotrexate
Compound (Entity type)
0.3902971744537353

5-(4-Chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
methotrexate
Compound (Entity type)
0.4252593517303467

methotrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
BUB1
Gene (Entity type)
-0.008435287

methotrexate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCDH9
Gene (Entity type)
-0.008600152

methotrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
F2RL1
Gene (Entity type)
0.0096849715

methotrexate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ATF3
Gene (Entity type)
0.011475772

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