N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TSPYL5 Gene (Entity type)	-0.019109162
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	thiazovivin Compound (Entity type)	0.2406261265277862
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1X Gene (Entity type)	0.028582478
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ATP11B Gene (Entity type)	-0.018617459
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPRC5A Gene (Entity type)	0.026235899
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PUF60 Gene (Entity type)	-0.04242601
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Aurora kinase B Protein (Entity type)	IC50
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RRS1 Gene (Entity type)	0.03902327
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MAGEA12 Gene (Entity type)	0.0254329
N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1G Gene (Entity type)	0.02587817

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TSPYL5
Gene (Entity type)
-0.019109162

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
thiazovivin
Compound (Entity type)
0.2406261265277862

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1X
Gene (Entity type)
0.028582478

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ATP11B
Gene (Entity type)
-0.018617459

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPRC5A
Gene (Entity type)
0.026235899

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PUF60
Gene (Entity type)
-0.04242601

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Aurora kinase B
Protein (Entity type)
IC50

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RRS1
Gene (Entity type)
0.03902327

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MAGEA12
Gene (Entity type)
0.0254329

N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1G
Gene (Entity type)
0.02587817

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