2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MAGEA3 Gene (Entity type)	-0.0059993835
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PYCR1 Gene (Entity type)	-0.005057175
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TSPAN13 Gene (Entity type)	0.007365087
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SLC12A2 Gene (Entity type)	0.0049989186
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Mitogen-activated protein kinase 7 Protein (Entity type)	Kd
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TUBB2A Gene (Entity type)	0.006363977
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Bromodomain-containing protein 4 Protein (Entity type)	IC50
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SLC30A1 Gene (Entity type)	0.005453801
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	0.6727030277252197
XMD8-92 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	0.7290952801704407

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MAGEA3
Gene (Entity type)
-0.0059993835

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PYCR1
Gene (Entity type)
-0.005057175

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TSPAN13
Gene (Entity type)
0.007365087

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SLC12A2
Gene (Entity type)
0.0049989186

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Mitogen-activated protein kinase 7
Protein (Entity type)
Kd

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TUBB2A
Gene (Entity type)
0.006363977

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Bromodomain-containing protein 4
Protein (Entity type)
IC50

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SLC30A1
Gene (Entity type)
0.005453801

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
0.6727030277252197

XMD8-92
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
0.7290952801704407

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