4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IFRD2 Gene (Entity type)	0.004975683
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DCLK1 Gene (Entity type)	-0.0037926727
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINA5 Gene (Entity type)	-0.0039833854
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	F13A1 Gene (Entity type)	-0.004150184
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AKR1B1 Gene (Entity type)	0.0044731726
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Malignant neoplasm of prostate Disease or Phenotype (Entity type)
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KRT14 Gene (Entity type)	0.004559047
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LCN2 Gene (Entity type)	0.0038474856
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TSPYL5 Gene (Entity type)	0.0046168906
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINB9 Gene (Entity type)	-0.0037864612

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
IFRD2
Gene (Entity type)
0.004975683

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DCLK1
Gene (Entity type)
-0.0037926727

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINA5
Gene (Entity type)
-0.0039833854

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
F13A1
Gene (Entity type)
-0.004150184

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AKR1B1
Gene (Entity type)
0.0044731726

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Malignant neoplasm of prostate
Disease or Phenotype (Entity type)

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KRT14
Gene (Entity type)
0.004559047

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LCN2
Gene (Entity type)
0.0038474856

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TSPYL5
Gene (Entity type)
0.0046168906

4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINB9
Gene (Entity type)
-0.0037864612

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